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April 10, 20260 citationsOpen Access

Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome

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RVRoberto Vendramin

Key Points

  • To examine how inhibiting nonsense-mediated mRNA decay affects the cancer immunopeptidome.
  • Collected and processed datasets from various experimental assays.
  • Included original western blot images for protein identification.
  • Used confocal microscopy to visualize cellular structures and processes.
  • Provided a comprehensive dataset showing alterations in the immunopeptidome.
  • Demonstrated changes in peptide presentation associated with mRNA decay pathways.

Abstract

This repository contains all processed datasets used to generate the figures in the associated manuscript (Vendramin et al., Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome, Immunity (2026), https://doi.org/10.1016/j.immuni.2026.02.005), including all original western blot images and raw confocal microscopy images.

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Cite This Study

Roberto Vendramin (2026) studied this question.

synapsesocial.com/papers/69d896a46c1944d70ce08387https://doi.org/10.5281/zenodo.10599407
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome2026 · 3 citations
  2. 2Abstract 6742: Nonsense-mediated mRNA decay inhibition augments <i>in vitro, in vivo</i> , and <i>ex vivo</i> anti-tumor immunity2026
  3. 3Abstract 2082: Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape2024
  4. 4Abstract 6737: Pharmacologic modulation of nonsense-mediated decay induces anti-tumor immunogenicity in <i>ex vivo</i> patient tumors2024 · 1 citations
  5. 5Abstract 5625: Targeting the nonsense mediated mRNA decay pathway to prevent the degradation of highly immunogenic frameshift mutated transcripts2024 · 1 citations