What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: End-stage renal disease receiving hemodialysis (n=174). Primary outcome: Clinically significant depressive symptoms (PHQ-9 score ≥10).

What does this research mean for the field?

Female gender, anemia, and higher comorbidity are independently associated with depressive symptoms in hemodialysis patients, while religious practice serves as a protective factor. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to identify factors contributing to depressive symptoms in patients undergoing hemodialysis.

April 15, 2026Blood Purification

Anemia is linked to ~10-fold higher odds of depressive symptoms in hemodialysis patients.

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Why the study?

Depression is the most prevalent psychiatric disorder in ESRD patients receiving hemodialysis and is linked to adverse clinical outcomes, prompting evaluation of its clinical and sociodemographic correlates.

Population

174 adults on hemodialysis for at least three months in a Portuguese center

Comparison

Clinical and sociodemographic variables associated with depressive symptoms (PHQ-9 score ≥10)

Design

Cross-sectional study

Key result

Female gender, anemia (OR 10.54; 95% CI 2.44-45.62), and higher comorbidity were independently associated with depressive symptoms in hemodialysis patients, while religious practice was protective.

Authors

MMMariana Jeremias Macedo BBBárbara Beirão RRRui Rodrigues

Discussion

Member takes

Overview

Supports targeted depression screening in high-risk hemodialysis patients; leaves open causality pending prospective validation.

Key Points

This study aims to identify factors contributing to depressive symptoms in patients undergoing hemodialysis.
Conducted a cross-sectional study in a Portuguese hemodialysis center
Sample included adults on hemodialysis for at least three months
Collected sociodemographic, clinical, and laboratory data
Assessed depressive symptoms with the Patient Health Questionnaire-9 (PHQ-9)
Analyzed associations using bivariate methods and multivariate logistic regression.
14 out of 174 patients (8%) displayed clinically significant depressive symptoms
Female gender, higher Charlson Comorbidity Index, and anemia were significantly associated with depression
Religious practice was inversely associated with depressive symptoms

Study Design

Type

Cross-Sectional (n=174)

Multicenter

Structured PICO

Population

174 adults (≥18 years) on hemodialysis for at least three months, mean age 70.2 ± 13.7 years, 61.5% male, in a Portuguese HD center. Excluded: cognitive impairment, communication difficulties, advanced malignancy, and acute debilitating illness.

Outcome

Clinically significant depressive symptoms assessed using the Patient Health Questionnaire-9 (PHQ-9) with scores ≥10patient reported

In hemodialysis patients, female gender, anemia, and higher comorbidity burden are associated with depressive symptoms, while religious practice appears protective.

Cite This Study

Macedo et al. (2026) conducted a cross-sectional in End-stage renal disease receiving hemodialysis (n=174). Female gender, anemia (OR 10.54; 95% CI 2.44-45.62), and higher comorbidity were independently associated with depressive symptoms in hemodialysis patients, while religious practice was protective.

synapsesocial.com/papers/69df2abce4eeef8a2a6afb71 https://doi.org/10.1159/000551823

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April 15, 2026Blood Purification

Anemia is linked to ~10-fold higher odds of depressive symptoms in hemodialysis patients.

View Full Paper

Ask AI

Bookmark

Why the study?

Population

174 adults on hemodialysis for at least three months in a Portuguese center

Comparison

Clinical and sociodemographic variables associated with depressive symptoms (PHQ-9 score ≥10)

Design

Cross-sectional study

Key result

Female gender, anemia (OR 10.54; 95% CI 2.44-45.62), and higher comorbidity were independently associated with depressive symptoms in hemodialysis patients, while religious practice was protective.

Authors

MMMariana Jeremias Macedo BBBárbara Beirão RRRui Rodrigues

Discussion

Member takes

Overview

Supports targeted depression screening in high-risk hemodialysis patients; leaves open causality pending prospective validation.

Key Points

This study aims to identify factors contributing to depressive symptoms in patients undergoing hemodialysis.
Conducted a cross-sectional study in a Portuguese hemodialysis center
Sample included adults on hemodialysis for at least three months
Collected sociodemographic, clinical, and laboratory data
Assessed depressive symptoms with the Patient Health Questionnaire-9 (PHQ-9)
Analyzed associations using bivariate methods and multivariate logistic regression.
14 out of 174 patients (8%) displayed clinically significant depressive symptoms
Female gender, higher Charlson Comorbidity Index, and anemia were significantly associated with depression
Religious practice was inversely associated with depressive symptoms

Study Design

Type

Cross-Sectional (n=174)

Multicenter

Structured PICO

Population

Outcome

Clinically significant depressive symptoms assessed using the Patient Health Questionnaire-9 (PHQ-9) with scores ≥10patient reported

In hemodialysis patients, female gender, anemia, and higher comorbidity burden are associated with depressive symptoms, while religious practice appears protective.

Cite This Study

synapsesocial.com/papers/69df2abce4eeef8a2a6afb71 https://doi.org/10.1159/000551823

Also Consider

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