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April 15, 2026Biochemistry Research InternationalOpen Access

Exploration of the In Vitro and In Vivo Neuroprotective Effects of Several Polyphenolics on LPS‐Induced Neuroinflammation

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Authors

MEMona ElkhatiebRRRasha Ali RadwanDEDoaa Abou El-ezz

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Overview

Exploration shows polyphenolics mitigate neuroinflammation in models, indicating natural treatments may help neuroprotection.

Key Points

  • The research aims to evaluate the neuroprotective effects of polyphenolic compounds on neuroinflammation caused by lipopolysaccharide (LPS).
  • Conducted in vitro and in vivo experiments
  • Evaluated cytotoxicity and nitric oxide production
  • Assessed antioxidant enzyme activities and iNOS expression
  • Performed behavioral assessments for cognitive function
  • Analyzed biomarkers of inflammation and apoptosis
  • Isoliquiritigenin, hesperidin, and curcumin reduced nitric oxide production
  • All compounds restored antioxidant enzyme activities
  • Treatments improved cognitive performance following LPS administration
  • Reduced levels of interleukin-1β and TNF-α in the hippocampus
  • Decreased expression of amyloid-β and caspase-3 levels

Cite This Study

Elkhatieb et al. (2026) studied this question.

synapsesocial.com/papers/69df2abce4eeef8a2a6afbafhttps://doi.org/10.1155/bri/1541212
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