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April 15, 2026JAIDS Journal of Acquired Immune Deficiency Syndromes0 citations

Diagnostic Performance of Fatty Liver Index for Hepatic Steatosis and its Association With Fibrosis in People Living With HIV

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ACAhmed CordieAKAhmed KamelRMRahma Mohamed

Key Points

  • Evaluate the effectiveness of the fatty liver index (FLI) in diagnosing hepatic steatosis (HS) and its relationship with fibrosis in people living with HIV.
  • Analyzed the diagnostic performance of the fatty liver index (FLI) against controlled attenuation parameter (CAP) measurements.
  • Assessed concordance of FLI results with CAP in people living with HIV.
  • Investigated the performance of FLI specifically in lean individuals within the population.
  • FLI missed nearly half of the hepatic steatosis cases defined by CAP.
  • Substantial limitations were found in screening for HS, especially in lean individuals.
  • FLI is not reliable as a standalone tool for diagnosing hepatic steatosis.

Abstract

FLI demonstrates substantial limitations as a screening tool for HS in people living with HIV, missing nearly half of CAP-defined cases. The poor concordance with CAP and particularly weak performance in lean individuals-who represent a significant proportion of PWH-indicate that FLI cannot reliably identify HS in this population and should not be used as a standalone diagnostic tool.

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Cite This Study

Cordie et al. (2026) studied this question.

synapsesocial.com/papers/69df2b2ce4eeef8a2a6b0197https://doi.org/10.1097/qai.0000000000003809
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