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April 15, 2026Diabetes Obesity and Metabolism0 citationsOpen Access

Differential Impact of Metabolic Bariatric Surgery Versus Semaglutide on Adverse Hepatic and Extrahepatic Outcomes in Individuals With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Type 2 Diabetes

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WSWeronika StupalkowskaAHAlex E. HenneyDRDavid R. Riley

Key Points

  • This research aims to compare the effects of metabolic bariatric surgery and semaglutide on liver and extrahepatic health outcomes in patients with metabolic dysfunction-associated liver disease and type 2 diabetes.
  • Compared metabolic bariatric surgery with semaglutide in patients with metabolic dysfunction and type 2 diabetes
  • Evaluated hepatic and extrahepatic outcomes including cirrhosis and heart failure
  • Utilized liver assessment to inform treatment decisions
  • Increased risk of metabolic adverse liver outcomes was noted with metabolic bariatric surgery compared to semaglutide
  • Metabolic bariatric surgery showed protective effects against major adverse cardiovascular events
  • First diagnosis of cirrhosis and heart failure was more frequently observed with metabolic bariatric surgery

Abstract

In patients with MASLD and T2D, MBS, and specifically RYGB, as compared to semaglutide, may drive a relatively increased risk of MALO despite protection against MACE, the first diagnosis of cirrhosis, heart failure, and OAC. Liver evaluation in individuals with T2D referred for MBS may help optimize their treatment.

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Cite This Study

Stupalkowska et al. (2026) studied this question.

synapsesocial.com/papers/69df2b2ce4eeef8a2a6b01a7https://doi.org/10.1111/dom.70757
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