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April 15, 2026International Journal of Molecular SciencesOpen Access

Single-Cell Immune Atlases to Map Small Extracellular Vesicle Cargo in Tuberculosis–Diabetes Comorbidity: A Narrative Review and Conceptual Roadmap

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Authors

RCRamona CioboatăSVSilviu Gabriel VlasceanuDMDenisa Maria Mitroi

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Overview

Narrative review explores immune dysfunction and small extracellular vesicles in tuberculosis–diabetes comorbidity, suggesting new insights.

Key Points

  • The review aims to bridge the gap between small extracellular vesicle cargo and immune dysfunction in tuberculosis–diabetes comorbidity.
  • Narrative review of studies from 2010 to 2026 focused on tuberculosis and diabetes mellitus.
  • Utilization of single-cell and multimodal immune reference atlases such as scRNA-seq and CITE-seq.
  • Development of frameworks for linking EV cargo to immune cell states and anatomic compartments.
  • Highlighting challenges in interpreting EV studies due to heterogeneous mixtures and selective cargo packaging.
  • Conventional analyses often overlook clinically relevant immune dysfunction in TB-DM.
  • Single-cell atlases could help identify specific immune cell states linked to EV cargo patterns.
  • Proposed frameworks aim to improve identification of biomarkers for treatment response and immunopathology.

Cite This Study

Cioboată et al. (2026) studied this question.

synapsesocial.com/papers/69df2b2ce4eeef8a2a6b0210https://doi.org/10.3390/ijms27083437
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