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April 15, 2026Journal of Virology0 citationsOpen Access

Ubiquitination of HPV-16 L1 Capsid Protein Regulates Viral Infection

Regulation of HPV-16 infection by ubiquitination of the L1 major capsid protein

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Authors

ÓTÓscar Trejo-CerroMMMartina Bergant MarušičPWPatryk Włodarczyk

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Overview

Demonstrates how ubiquitination affects HPV-16 infection in host cells, suggesting new therapeutic targets.

Key Points

  • The aim is to understand the impact of ubiquitination on HPV-16 L1 protein's role in the viral life cycle.
  • Identification of lysine residues on L1 protein using mass spectrometry
  • Mutation analysis of specific lysines to assess effects on pseudovirion formation
  • Assessment of infectivity in various epithelial cell lines after pre-incubation with an anti-ubiquitin antibody
  • K64 and K152 mutations prevent pseudovirion formation, while others allow formation but lower infectivity
  • Pre-incubation with anti-ubiquitin antibody significantly reduces pseudovirion infectivity
  • K452 and K454 are crucial for efficient infectious entry and intracellular trafficking

Cite This Study

Trejo-Cerro et al. (2026) studied this question.

synapsesocial.com/papers/69df2ba0e4eeef8a2a6b09behttps://doi.org/10.1128/jvi.00285-26
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