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April 15, 2026Cancer Medicine0 citationsOpen Access

Second Line Treatment Decision as Per Standard of Care or Foundation Medicine in Patients With Locally Advanced or Metastatic Non‐Small Cell Lung Cancer

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FRF. G. RojoEFEnriqueta FelipÓVÓscar Vidal

Key Points

  • This research aims to evaluate the impact of Foundation Medicine (FMI) genomic profiling on treatment decisions for advanced non-small cell lung cancer (NSCLC).
  • Utilized FMI genomic profiling data to assess treatment pathways.
  • Compared treatment decisions between standard of care (SOC) and FMI recommendations.
  • Directed eligible patients towards clinical trials based on their genomic data.
  • Clinicians modified management strategies for several NSCLC patients.
  • FMI identified actionable mutations that SOC approaches missed.
  • The findings highlight FMI's potential to enhance personalized medicine in NSCLC treatment.

Abstract

Using FMI data, clinicians were able to direct patients toward clinical trials and to modify SOC clinical management for several NSCLC patients. These results demonstrate the benefit of FMI genomic profiling in identifying actionable driver mutations that would otherwise be missed by SOC methodology. The findings suggest that CGP is a promising and robust tool for improving personalized medicine in NSCLC treatment in Spain.

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Cite This Study

Rojo et al. (2026) studied this question.

synapsesocial.com/papers/69df2ba0e4eeef8a2a6b09fbhttps://doi.org/10.1002/cam4.71790
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