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April 15, 2026Vascular Health and Risk Management0 citationsOpen Access

Hemodynamic-Guided Therapy Improves Blood Pressure Control in Patients with Cardiovascular Disease

Hemodynamic-Guided Therapy is Associated with Better Hypertension Control Compared with Standard Care: A Comparative Clinical Analysis

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Why the study?

Blood pressure abnormalities are common in patients with heart-related conditions and substantially increase morbidity and mortality, prompting evaluation of hemodynamic-guided therapy compared with standard care.

Does hemodynamic-guided therapy improve systolic and diastolic blood pressure in patients with cardiovascular disease compared with standard care?

Population

156 patients with cardiovascular disease

Comparison

Hemodynamic-guided therapy vs standard care

Design

Retrospective comparative study

Key result

Hemodynamic-guided therapy significantly reduced systolic blood pressure to 132.11 mmHg compared to 153.18 mmHg with standard care in patients with hypertension and cardiovascular comorbidities.

Authors

YNYasser NassefHTHsiao‐En TsaiKCKuei‐Chuan Chan

Discussion

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Overview

HGT may improve BP control versus standard care in CVD; hypothesis-generating and requires RCTs before practice change.

Key Points

  • The study aims to evaluate the effectiveness of hemodynamic-guided therapy in managing hypertension compared to standard care.
  • Retrospective analysis of 156 patients with cardiovascular disease
  • Comparison of systolic and diastolic blood pressure changes between HGT and standard care
  • Use of hemodynamic parameters for medication selection in HGT
  • Statistical analysis including paired t-tests and chi-square tests
  • Significant reductions in both systolic and diastolic blood pressure in the HGT group (p < 0.001)
  • Post-treatment average SBP in women receiving HGT was 133.8 mmHg
  • Post-treatment average SBP in men receiving HGT was 131.6 mmHg, down from 150.5 mmHg
  • DBP decreased to 74.2 mmHg in women and 74.7 mmHg in men receiving HGT, both p < 0.001
  • No significant changes in blood pressure were observed in the control group

Study Design

Type

Cohort (n=156)

Multicenter

No

Structured PICO

Does hemodynamic-guided therapy improve systolic and diastolic blood pressure in patients with cardiovascular disease compared with standard care?

P
Population
156 patients with cardiovascular disease (n=107 in HGT group, n=49 in control group)
I
Intervention
Hemodynamic-guided therapy (HGT) using standardized noninvasive hemodynamic monitoring (cardiac output, systemic vascular resistance, and total body fluids) to guide medication selection and titration
C
Comparator
Standard care
O
Outcome
Changes in systolic and diastolic blood pressure (SBP, DBP) from baseline to post-treatmentsurrogate

Hemodynamic-guided therapy using noninvasive monitoring to titrate medications may significantly improve blood pressure control in patients with cardiovascular disease compared to standard care.

Main Result

Absolute Event Rate: 132.11% vs 153.18%

p-value: p=<0.001

Limitations

  • Retrospective and nonrandomized design cannot establish causation
  • Potential selection bias in patient referral for HGT
  • Unmeasured confounding such as medication adherence, lifestyle changes, and concurrent therapies
  • Limited sample size and short follow-up duration
  • Heterogeneity in HGT implementation and usual-care practices
  • Relied on clinic blood pressure measurements without consistent ambulatory or home monitoring
  • Imbalance in sex distribution between groups
  • Retrospective analysis

Cite This Study

Nassef et al. (2026) conducted a cohort in Hypertension and cardiovascular disease (n=156). Hemodynamic-Guided Therapy (HGT) vs. Standard care was evaluated on Post-treatment systolic blood pressure (mmHg) (p=<0.001). Hemodynamic-guided therapy significantly reduced systolic blood pressure to 132.11 mmHg compared to 153.18 mmHg with standard care in patients with hypertension and cardiovascular comorbidities.

synapsesocial.com/papers/69df2bece4eeef8a2a6b0d6ehttps://doi.org/10.2147/vhrm.s587746
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