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April 15, 2026mSystemsOpen Access

TSPO safeguards porphyrin–iron balance under anoxic conditions in Bacillus cereus

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Authors

CDCatherine DuportCSCaroline SchmittJAJean Armengaud

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Overview

Demonstrates the role of TSPO in maintaining iron and porphyrin balance in Bacillus cereus, suggesting its importance for metabolic stability under low oxygen conditions.

Key Points

  • This research aims to elucidate the physiological role of TSPO in maintaining porphyrin and iron balance in Bacillus cereus under anoxic conditions.
  • Deletion of tspO gene in Bacillus cereus under fermentative anoxic conditions
  • Cellular proteome analyses to assess metabolic changes
  • Evaluation of redox balance and growth characteristics
  • Increased porphyrin accumulation and redox imbalance observed in ΔtspO mutant
  • Extensive remodeling of central metabolism noted, including changes in protein abundances related to iron and nitrate metabolism
  • Induction of NO-detoxifying systems indicating nitrosative stress in the mutant

Cite This Study

Duport et al. (2026) studied this question.

synapsesocial.com/papers/69df2bece4eeef8a2a6b0d96https://doi.org/10.1128/msystems.01738-25
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Also Consider

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