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April 15, 2026GeroScienceOpen Access

Conserved trajectories of age-related thigmotaxis across insects and mammals reveal the house cricket as a scalable model for behavioral aging

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Authors

GLGerald Yu LiaoJKJenna KlugSSSwastik Singh

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Overview

This research shows conserved exploratory decline in crickets and mice, suggesting practical interventions for aging behaviors.

Key Points

  • To explore the evolutionary conservation of age-related thigmotaxis across species and its implications for behavioral aging.
  • Examined thigmotaxis in house crickets and C57BL/6 J mice in open-field tests.
  • Used lifespan- and maturity-normalized metrics to assess age-related behavior across species.
  • Analyzed thigmotaxis patterns in CB6F1 hybrid mice in comparison to crickets and standard mouse strains.
  • House crickets showed significant increases in thigmotaxis with age, akin to patterns seen in aging mice.
  • CB6F1 hybrid mice maintained lower levels of thigmotaxis, indicating resilience to exploratory decline.
  • The findings suggest a conserved neurobehavioral mechanism for cognitive decline across insects and mammals.

Cite This Study

Liao et al. (2026) studied this question.

synapsesocial.com/papers/69df2bece4eeef8a2a6b0dc1https://doi.org/10.1007/s11357-026-02239-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Age-related cognitive decline in house crickets reveals conserved patterns of sensory and learning deficits across the lifespan2025 · 3 citations
  2. 2Age-Related Behavioral Changes Across the Adult Lifespan of a Cricket: A Longitudinal Analysis Using DeepLabCut2026
  3. 3A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket2026
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  5. 5Home-Cage Monitoring Methods Reveal Age- and Strain-Related Differences in Motor, Thermal, and Cognitive Functions in Male Mice of Two Inbred Strains2026