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April 15, 2026Analytical Chemistry

Quantitatively Sensing Lipid Droplets Polarity in Cells and Atherosclerotic Model with a Novel Naphthalimide-Based Fluorescent Probe

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Authors

RLRui LiRZRi ZhouWSWei Shi

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Overview

Quantitative analysis of lipid droplets polarity in atherosclerosis, indicating diagnostic potential for plaque detection.

Key Points

  • This research aims to develop a novel fluorescent probe to quantify the polarity of lipid droplets, particularly in the context of atherosclerosis.
  • Development of the naphthalimide-based probe Lipi-NIFD
  • Use of hyperspectral fluorescence imaging (HSFI) to detect polarity changes
  • Application of the probe in aorta, liver, and AS plaque of model mice
  • Lipi-NIFD shows high fluorescence quantum yield and polarity sensitivity
  • Quantitative mapping reveals significantly lower LDs polarity in AS plaque compared to aorta
  • LDs polarity in AS plaque is substantially lower (E_T(30) = 32.90 kcal mol^-1) than in major aorta region (E_T(30) = 33.89 kcal mol^-1)

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69df2bece4eeef8a2a6b0e32https://doi.org/10.1021/acs.analchem.6c00280
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