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April 15, 2026EJNMMI Physics0 citationsOpen Access

Contrast-enhanced CT for attenuation correction in ultra-high sensitivity long-axial field-of-view lymphoma PET: amplified quantification problems?

JPJan-Luca PennerABAugust BlomgrenAWAlexander Weissensee

Key Points

  • The aim is to evaluate the impact of CE-CT on SUV measurements in LAFOV-PET for lymphoma.
  • Utilized CE-CT for attenuation correction in LAFOV-PET imaging.
  • Assessed SUV measurements in lymphoma lesions under ultra-high sensitivity mode.
  • Compared findings with conventional standard axial field-of-view PETs.
  • Observed higher SUV measurements in lymphoma lesions using CE-CT.
  • Noted increased quantification problems compared to standard axial PET.
  • Highlighted the need for careful interpretation of borderline cases.

Abstract

The use of CE-CT for AC of LAFOV-PET in UHS mode leads to higher SUV measurements. Also, lymphoma lesions show a consistent increase in uptake. The errors in the lesions seem higher than in conventional standard axial field-of-view PETs that use CE-CT for AC. Therefore, interpretation of borderline cases warrants attention to potential errors.

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Cite This Study

Penner et al. (2026) studied this question.

synapsesocial.com/papers/69df2c01e4eeef8a2a6b0ecehttps://doi.org/10.1186/s40658-026-00866-4
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