This narrative review examines tumor microenvironment interactions in melanoma, highlighting their impact on tumor behavior and therapy outcomes.
Key Points
The review aims to synthesize current knowledge on the cellular and non-cellular constituents of the cutaneous melanoma microenvironment and their roles in tumor progression and therapy resistance.
Conducted a narrative review of recent studies on melanoma-microenvironment interactions.
Integrated evidence from in vitro, in vivo, and human tissue analyses.
Analyzed contributions of diverse cellular populations and signaling pathways.
Identified intra-tumoral heterogeneity driven by genetic and microenvironmental factors.
Highlighted roles of immune subsets in promoting both immune suppression and improved outcomes.
Described the impact of ECM remodeling on tumor growth and immune evasion.