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November 25, 2005European Heart JournalOpen Access

Role of angiotensin system and effects of its inhibition in atrial fibrillation: clinical and experimental evidence

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Why the study?

Do ACE-inhibitors and ARBs prevent atrial remodelling and maintain sinus rhythm in patients with atrial fibrillation?

Population

Patients with atrial fibrillation, particularly those with left ventricular hypertrophy or failure

Design

Review

Authors

JEJoachim R. EhrlichSHStefan H. HohnloserSNStanley Nattel

Discussion

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Overview

Should not change AF practice without other indications; leaves open dedicated RCT confirmation of remodelling benefit.

Structured PICO

Do ACE-inhibitors and ARBs prevent atrial remodelling and maintain sinus rhythm in patients with atrial fibrillation?

P
Population
Patients with atrial fibrillation, particularly those with left ventricular hypertrophy or failure
I
Intervention
Angiotensin converting-enzyme (ACE)-inhibitors and angiotensin-receptor blockers (ARBs)
O
Outcome
Maintenance of sinus rhythm and prevention of atrial structural and electrical remodelling

ACE inhibitors and ARBs may help prevent atrial remodeling and treat AF, especially in patients with LV hypertrophy or heart failure, though definitive randomized trial data is still needed.

Limitations

  • Lack of prospective randomized double-blind trials data

Cite This Study

Ehrlich et al. (2005) studied this question.

synapsesocial.com/papers/6a0227fc0cec8eebbd5cc47ehttps://doi.org/10.1093/eurheartj/ehi668
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