FIGURE 1 from Evaluation of Copanlisib in Combination with Eribulin in Triple-negative Breast Cancer Patient-derived Xenograft Models

PI3K pathway alterations of selected TNBC PDX models. A, Molecular characteristics of the eight TNBC PDX models included in this study, including mutation status of candidate genes based on whole exome sequencing, breast cancer intrinsic subtype and TNBC subtype derived from gene expression profiling, and PI3K pathway signaling activity indicated by levels of AKT phosphorylation and PTEN by RPPA analysis for each model. B, Representative pictures of PTEN IHC, demonstrating loss of PTEN expression in four of the eight PDX models. The number at the right lower corner of each IHC picture refers to the WHIM ID of the PDX model analyzed. Note the positive PTEN staining of the stromal cells, which serves as an internal control.