What question did this study set out to answer?

To develop and characterize cycloruthenated imines as novel antiproliferative agents with high potency.

January 18, 2026Open Access

Cycloruthenated Imines: A Step into the Nanomolar Region

Key Points

To develop and characterize cycloruthenated imines as novel antiproliferative agents with high potency.
Synthesis of cycloruthenated imines from benzene and thiophene carbaldehydes.
Characterization using UV-Vis spectroscopy, X-ray diffraction, NMR, HRMS, and cyclic voltammetry.
Biological testing against A2780, cisplatin-resistant A2780, and HEK293 cell lines.
Compounds exhibited nanomolar IC50 values indicating high potency in inhibiting cell growth.
Reported selectivity index of up to 2.5, suggesting ability to differentiate between healthy and cancer cells.

Abstract

A new series of promising and easily accessible antiproliferative agents based on cycloruthenated imines of benzene and thiophene carbaldehydes has been developed and fully characterized using UV-Vis spectroscopy, X-ray diffraction, NMR, HRMS, and cyclic voltammetry. The biological activity of these compounds was tested against A2780, cisplatin-resistant A2780, and HEK293 cell lines, and they exhibited nanomolar IC50 values. They also showed a selectivity index of up to 2.5, indicating their potential as promising antiproliferative compounds.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

А. Н. Васильев

Ivan I. Troshin

Pavel G. Shangin

Journals

Molecules

Actions

Institutions

Lomonosov Moscow State University

N.D. Zelinsky Institute of Organic Chemistry

MIREA - Russian Technological University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Cycloruthenated Imines: A Step into the Nanomolar Region

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study