Beyond Parkinsonism: 18F-FDOPA Brain PET/MRI for Detection of High-grade Glioma

Puntos clave

• This case aims to explore the use of 18F-FDOPA brain PET/MRI for detecting high-grade gliomas in atypical parkinsonism cases.
• Case report of a 72-year-old man with atypical parkinsonism symptoms.
• Initial MRI assessed for degenerative parkinsonism and noted hyperintensity in the splenium.
• 18F-FDOPA brain PET/MRI performed to evaluate tracer uptake in the brain.
• Contrast-enhanced MRI followed after PET results indicated atypical findings.
• Stereotactic biopsy confirmed diagnosis of high-grade glioblastoma.
• Initial MRI suggested small vessel disease, ruling out degenerative parkinsonism.
• 18F-FDOPA PET/MRI indicated high tracer uptake in the splenium (SUVmax 4.46).
• Contrast-enhanced MRI revealed a lesion concerning for neoplasm.
• Biopsy results confirmed diffuse high-grade glioblastoma, IDH-wildtype, WHO Grade 4.

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