Temperature Dependent Divergent Radical Oxidative Amidation Engaging Arylglyoxyl Radicals

Puntos clave

• The research aims to explore the synthesis of arylglyoxyl amides and aromatic amides through a new radical oxidative amidation process.
• Generated arylglyoxyl radicals from arylglyoxals in situ.
• Utilized tert-butyl hydroperoxide and iodine as catalysts.
• Conducted reactions at two different temperatures (120 °C and 180 °C).
• Examined the reaction outcomes with various amines.
• At 120 °C, arylglyoxyl amides were formed.
• At 180 °C, aromatic amides were synthesized.
• Decarbonylation at higher temperature generated aroyl radicals for further reactions.

Resumen