Ultrasound and SNP-based cell-free DNA zygosity testing in twin pregnancies

Key Points

• The research aims to evaluate the effectiveness of cell-free DNA zygosity testing in determining chorionicity in twin pregnancies.
• Analysis of postpartum placental pathology data as a reference standard.
• Assessment of cfDNA zygosity testing's accuracy for identifying monochorionic and dichorionic twins.
• Comparison between results of zygosity testing and placental pathology outcomes.
• cfDNA zygosity testing shows promise for accurate chorionicity assignment in twin pregnancies.
• Larger studies are recommended to validate findings and improve management approaches.

Abstract