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This research aims to outline effective treatment strategies for pulmonary mucormycosis and highlight future areas of investigation.

January 25, 2026

Treatment of pulmonary mucormycosis: current concepts

Key Points

This research aims to outline effective treatment strategies for pulmonary mucormycosis and highlight future areas of investigation.
Early recognition of pulmonary mucormycosis cases
LAMB induction for initial treatment
Optimization of host factors
Multidisciplinary surgical assessment
Oral triazole for maintenance therapy
Prompt treatment improves patient outcomes
Combination therapy is reserved for severe cases due to insufficient evidence
Emerging antifungals warrant further research
Future studies should assess novel treatment strategies and host-directed therapies

Abstract

Optimal care of PM requires early recognition, prompt LAMB induction with rigorous host factor optimization, multidisciplinary surgical assessment, followed by oral triazole maintenance. Combination antifungal therapy lacks definite evidence and should be reserved for severe or refractory cases. Future research priorities include prospective evaluation of treatment strategies, host-directed therapies, emerging antifungals (oral nanocrystal amphotericin, fosmanogepix, etc.), and systematic assessment of adjunctive modalities.

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Authors

Valliappan Muthu

Inderpaul Singh Sehgal

Ritesh Agarwal

Journals

Expert Review of Anti-infective Therapy

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Treatment of pulmonary mucormycosis: current concepts

Key Points

Abstract

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Discussion

Authors

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References and Citations

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