Impact of insertion/deletion mutations a3ecting the ABL1 gene in Phpositive leukemias

Key Points

• To evaluate how insertion and deletion mutations in the ABL1 gene influence the characteristics of Ph-positive leukemias.
• Analyzed genetic samples from patients with Ph-positive leukemias.
• Identified and classified insertion and deletion mutations in the ABL1 gene.
• Correlated mutation types with disease progression and treatment response.
• Insertion and deletion mutations were found to significantly impact patient outcomes.
• Certain mutations were associated with quicker disease progression.
• Findings suggest that genetic testing for ABL1 mutations could guide treatment decisions.

Abstract