A Role for Non‐Canonical Caspases in Fungal Allergic Airway Disease

Key Points

• The aim is to explore the role of non-canonical caspases in allergic fungal airway disease and their potential as therapeutic targets.
• Inhibition of caspase-11 in murine models.
• Assessment of neutrophilia and cytokine levels.
• Evaluation of wedelolactone and its derivatives as potential therapies.
• Reduced neutrophilia was observed with caspase-11 inhibition.
• Inflammatory cytokine levels decreased significantly.
• Wedelolactone derivatives show promise for treating resistant inflammation.

Abstract