What does this research mean for the field?

Home-based inspiratory muscle training (IMT) improves cardiac autonomic regulation, respiratory function, and sleep quality in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the impact of home-based inspiratory muscle training on sympatho-vagal balance and quality of life in patients with systemic sclerosis-associated interstitial lung disease.

February 17, 2026Open Access

Effects of home-based inspiratory muscle training on sympatho-vagal balance, quality of life, and inflammatory profile in patients with systemic sclerosis-associated interstitial lung disease

Key Points

To evaluate the impact of home-based inspiratory muscle training on sympatho-vagal balance and quality of life in patients with systemic sclerosis-associated interstitial lung disease.
Conducted a home-based inspiratory muscle training program
Assessed cardiac autonomic regulation
Evaluated respiratory function and quality of sleep
Monitored inflammatory markers
IMT significantly improved autonomic regulation of the heart
Showed enhancements in respiratory function
Improved sleep quality reported by patients
Indications of a mild anti-inflammatory effect observed

Abstract

IMT significantly enhanced cardiac autonomic regulation along with improvements in respiratory function and sleep quality in SSc-ILD patients and demonstrated slight indications of an increased anti-inflammatory effect. These findings highlight IMT as a promising non-pharmacological intervention to improve autonomic function, offering potential cardioprotective and clinical benefits for SSc patients.

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Discussion

Authors

Chiara Bellocchi

Marco Vicenzi

Angelica Carandina

Journals

European journal of medical research

Actions

Institutions

University of Milan

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Metropolitana Milanese (Italy)

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Effects of home-based inspiratory muscle training on sympatho-vagal balance, quality of life, and inflammatory profile in patients with systemic sclerosis-associated interstitial lung disease

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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