Abstract Alternative splicing (AS) significantly enhances transcriptomic diversity, and its dysregulation is implicated in numerous human diseases. However, no public database systematically compiles sex-related AS events across human tissues. We developed SASdb ( http://www.gdbioinfo.top/sasdb ), a comprehensive database contains 2,951,059 AS events and 46,418 sex-biased alternative splicing (SAS) events, covering 22 human tissues. SASdb reveals extensive sex-specific splicing patterns, offering new insights into molecular sex differences. A case study on NSCLC-specific SAS events, absent in healthy tissues, highlights their enrichment in cancer-related pathways like autophagy, GPI-anchor biosynthesis, and AMPK/mTOR signaling. SASdb’s intuitive visualization supports research in sex biology and precision medicine.
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Xi Chen
Yueqi Lu
You Rong Duan
Biology of Sex Differences
Zhejiang University
Sichuan University
University of Electronic Science and Technology of China
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Chen et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69a287b00a974eb0d3c038c6 — DOI: https://doi.org/10.1186/s13293-026-00861-5
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