The WAVE balloon with three inflation cycles increased total number of fragments to 112.6 versus 48.6 with standard balloon single inflation and reduced large fragments >9 mm to 7.6 versus 13.2 (p < 0.001).
Does the WAVE concept increase fragmentation and reduce large fragments in an in vitro model of calcified arterial stenosis compared to standard PTA?
In vitro model of below-the-knee (BTK) calcified arterial stenosis (3 mm outer diameter, 1.5 mm internal diameter, 7.2 cm length) made of paraffin wax, carnauba wax, and calcium carbonate. Total n=30 experiments.
WAVE concept: WAVE balloon (3 mm x 80 mm) with three inflation cycles (up to 14 atm) and a slight shift (advanced 3 mm, then retracted 1.5 mm) after each inflation.
Standard percutaneous transluminal angioplasty (PTA): standard balloon (Bard Ultraverse 0.014, 3 mm x 80 mm) with a single inflation cycle.
Total number of fragments and the number of large fragments (exceeding 9 mm in length) after angioplasty.surrogate
The WAVE balloon concept with multiple shifted inflations significantly increases fragmentation and reduces large fragments in an in vitro calcified stenosis model, suggesting potential for improved angioplasty outcomes.
The WAVE concept creates more and smaller fragments in a below-the-knee calcified arterial in vitro model. These findings show promising potential to improve the outcomes of future angioplasty procedures.
Building similarity graph...
Analyzing shared references across papers
Loading...
Oliver Andrew Binkert
Christoph Andreas Binkert
Thomas Frauenfelder
CVIR Endovascular
University of Zurich
University Hospital of Zurich
Building similarity graph...
Analyzing shared references across papers
Loading...
Binkert et al. (Sat,) conducted a other in Calcified arterial lesions in below-the-knee (BTK) arteries modeled in vitro. WAVE balloon with three inflation cycles and slight balloon shift after each inflation (WAVE concept) vs. Standard angioplasty balloon with single inflation cycle (standard PTA) was evaluated on Total number of fragments and number of fragments exceeding 9 mm in length generated by balloon angioplasty (p < 0.001, 95% CI 112.6 (95% CI [103.3, 121.9]) fragments vs. 48.6 (95% CI [42.5, 54.7]) fragments; fragments >9mm: 7.6 (95% CI [6.4, 8.8]) vs. 13.2 (95% CI [11.6, 14.8]), p=<0.001). The WAVE balloon with three inflation cycles increased total number of fragments to 112.6 versus 48.6 with standard balloon single inflation and reduced large fragments >9 mm to 7.6 versus 13.2 (p < 0.001).
www.synapsesocial.com/papers/69a52df3f1e85e5c73bf130c — DOI: https://doi.org/10.1186/s42155-026-00662-2