What question did this study set out to answer?

This research aims to explore the protective effects of MOTS-c against liver injury induced by acetaminophen (APAP) and the underlying mechanisms involved.

March 3, 2026

MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway

Puntos clave

This research aims to explore the protective effects of MOTS-c against liver injury induced by acetaminophen (APAP) and the underlying mechanisms involved.
Administered MOTS-c to mice exposed to acetaminophen
Evaluated liver injury markers such as oxidative stress and inflammation
Analyzed the MAPK signaling pathway components including ERK, JNK, and p38
MOTS-c administration significantly reduced liver injury in mice
The study found lower levels of oxidative stress and inflammation in treated mice
MAPK signaling pathway suppression was confirmed, correlating with reduced cell death

Resumen

This study demonstrates that administering MOTS-c effectively protects against APAP-induced liver injury in mice. The protective mechanism involves suppressing the damaging MAPK signaling pathway (ERK, JNK, p38), which in turn reduces oxidative stress, inflammation, and cell death.

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Discussion

Authors

N. Li

Yan Xu

Q. CHEN

Journals

Protein and Peptide Letters

Actions

Institutions

Nanjing Drum Tower Hospital

Xuzhou Medical College

Maternal and Child Health Hospital of Xuzhou

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway

Puntos clave

Resumen

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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