Early-phase directional brain connectivity analysis reveals that pharmacological and neurostimulation treatments engage distinct neural oscillatory mechanisms within the first week. Elevated baseline right-dominant α-band causal transmission identifies patients unlikely to respond to pharmacological treatment, enabling alternative interventions before weeks of ineffective therapy. These phase-based causality metrics offer promising biomarkers for early treatment stratification and monitoring. The ability to distinguish treatment responders from nonresponders at baseline and detect treatment-specific changes within one week, before clinical response manifestation, suggests these causality measures capture early mechanistic alterations that could inform timely treatment optimization decisions. (EUDRACT Nos. 2005-000826-22 and 2015-001639-19, registered via www.clinicaltrialsregister.eu).
Building similarity graph...
Analyzing shared references across papers
Loading...
Madhurima Bhattacharjee
Ioannis Vlachos
Aditi Kathpalia
Frontiers in Psychiatry
Charles University
Aristotle University of Thessaloniki
Czech Academy of Sciences
Building similarity graph...
Analyzing shared references across papers
Loading...
Bhattacharjee et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69a75a7ec6e9836116a205be — DOI: https://doi.org/10.3389/fpsyt.2025.1718216
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: