March 3, 2026Open Access

Weight trajectories throughout adulthood and prostate cancer incidence, aggressiveness, and death in 258 494 men

Key Points

Late midlife weight gain is linked to a higher risk of prostate cancer death, emphasizing the role of weight management.
The impact of PSA testing on detecting prostate cancer remains uncertain, highlighting potential biases.
Analysis involved 258,494 men, focusing on their weight trajectories throughout adulthood.
Weight management during midlife may serve as a crucial, modifiable factor for reducing prostate cancer mortality.

Abstract

The associations observed for incident PCa appear to be influenced by PSA testing uptake; however, the extent to which detection bias contributes remains uncertain. Conversely, late midlife weight gain was associated with an elevated risk of PCa death, underscoring the importance of weight management during this period as a potentially modifiable factor for reducing PCa death.

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Authors

Marisa Da Silva

Josef Fritz

Ahmed Elhakeem

Journals

JNCI Journal of the National Cancer Institute

Actions

Institutions

Karolinska Institutet

University of Bristol

Utrecht University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Weight trajectories throughout adulthood and prostate cancer incidence, aggressiveness, and death in 258 494 men

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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