Cantharidic acid causes mitochondrial dysfunction via the Nrf2/HO-1/GPX4 pathway to inhibit colorectal cancer progression.

Key Points

• Mitochondrial dysfunction caused by cantharidic acid leads to inhibited colorectal cancer progression, highlighting its therapeutic promise.
• The metric shows that cantharidic acid effectively blocks the nrf2/ho-1/gpx4 pathway, resulting in apoptotic effects on cancer cells.
• Assessment using the nrf2/ho-1/gpx4 pathway analysis demonstrates cantharidic acid's role in causing mitochondrial dysfunction.
• This finding supports cantharidic acid as a potential therapeutic agent; further clinical validation is warranted.

Abstract