March 3, 2026Open Access

IgA-Producing B Cells Exert Regulatory Function Through Granzyme B in Kidney Allograft Tolerance

Key Points

Tolerant kidney transplant recipients exhibit increased IgA+ and GZMB+ Bregs, enhancing suppressive properties.
A significant association exists between IgA+ and GZMB+ Bregs, indicating a potential mechanism for tolerance.
Assessment of B cell populations reveals that higher GZMB expression correlates with greater suppressive effects.
Findings highlight the importance of IgA-producing B cells in promoting tolerance through granzyme B activity.

Abstract

These data show a strong association between IgA+ and GZMB+ Bregs, particularly in tolerant kidney transplant recipients with higher GZMB and IgA expression and greater suppressive properties.

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Discussion

Authors

Laureline Berthelot

Nicolas Degauque

Laura Cappelier

Journals

Kidney360

Actions

Institutions

Inserm

Nantes Université

Centre Hospitalier Universitaire de Nantes

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

IgA-Producing B Cells Exert Regulatory Function Through Granzyme B in Kidney Allograft Tolerance

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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