March 3, 2026Open Access

Assessing cortical bone changes with Romosozumab after one year: Insights from an exploratory HR-pQCT study

Key Points

Rapid cortical bone improvements were detected in 56% of treatment responders at 6 months, indicating effective intervention.
Cortical bone changes were assessed using high-resolution peripheral quantitative computed tomography (HR-pQCT).
Patients were stratified based on changes in cortical thickness (Ct.Th) to identify those responsive to Romosozumab treatment.
Future investigations are needed to explore clinical predictors of responsiveness and potential adjustments to treatment duration.

Abstract

By stratifying patients based on Ct.Th changes, we identified treatment responders (56%) with rapid cortical bone improvements detectable at 6 monthsIdentifying clinical predictors of ROMO responsiveness and determining whether shorter treatment durations may be justified in selected patients warrant further investigation.

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Authors

María Belén Zanchetta

Mariana Gonzalez Pernas

Fernando Jerkovich

Journals

SHILAP Revista de lepidopterología

Bone Reports

Actions

Institutions

Universidad del Salvador

Instituto de Diagnóstico e Investigaciones Metabólicas

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Assessing cortical bone changes with Romosozumab after one year: Insights from an exploratory HR-pQCT study

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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