Tanshinone IIA&Icaritin -MPs regulated vascular normalization and restored tumor-infiltrating T lymphocyte function to boost anti-PD-1 therapy in melanoma lung metastasis

Key Points

• Vascular normalization correlates with enhanced tumor-infiltrating T lymphocyte function in melanoma.
• Key evidence shows that the combination of tanshinone IIA and icaritin improved T lymphocyte activity and tumor response.
• Assessment using vascular and immune profiling indicates how these agents interact with the tumor microenvironment.
• These findings may enable better therapeutic strategies against melanoma, highlighting the potential for combined treatments.