Cortical excitation does not drive changes in skin sympathetic nerve activity during single-pulse transcranial magnetic stimulation in humans

Key Points

• Skin sympathetic nerve activity remains unchanged despite cortical excitation during transcranial magnetic stimulation, indicating a disconnection between the two.
• Participants experienced consistent nerve activity responses following single-pulse transcranial magnetic stimulation, suggesting stable physiological mechanisms.
• Observational analysis across varied subjects reveals no significant correlation between cortical excitation and nerve activity metrics.
• These findings call for further investigation into the pathways involved, as current insights may indicate complexities not fully understood.