March 3, 2026Open Access

Regulatory dynamics of IFI44L in systemic lupus erythematosus: the interplay of type I interferon and c-Jun

Key Points

Enhanced expression of IFI44L indicates its critical role in systemic lupus erythematosus.
Type I interferon was shown to increase IFI44L expression by engaging c-Jun, affecting disease dynamics.
Assessment suggests modulation of IFI44L expression could be a target for therapeutic intervention in autoimmune conditions.
The findings highlight the importance of regulatory mechanisms involving IFN-α and c-Jun in the pathogenesis of SLE.

Abstract

Our research indicates that IFN-α enhances IFI44L expression via c-Jun, underscoring its critical role in the pathogenesis of SLE and suggesting potential pathways for therapeutic intervention.

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Discussion

Authors

Yuan Wang

Mengyi Yang

Hua Ma

Journals

Lupus Science & Medicine

Actions

Institutions

Ningxia Medical University

Ningxia Medical University General Hospital

References and Citations

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Building similarity graph...

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Regulatory dynamics of IFI44L in systemic lupus erythematosus: the interplay of type I interferon and c-Jun

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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