March 3, 2026Open Access

First computational characterization of HTR5A-AS1: a schizophrenia-linked antisense RNA with synaptic functions

Key Points

HTR5A-AS1 appears to play a critical role in synaptic functions, impacting schizophrenia risk.
This study identifies HTR5A-AS1 as an important antisense transcript involved in neuronal development and signaling.
Observational analysis indicates the need for future single-cell studies to further understand regulatory mechanisms.
Further functional perturbation studies are essential to establish causality related to schizophrenia development.

Abstract

These findings provide the first evidence that HTR5A-AS1 is a bona fide antisense transcript with developmental and synaptic roles that may contribute to schizophrenia risk. Future single-cell and functional perturbation studies are needed to test causality and define mechanisms of regulation.

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Authors

Grant H. Ruttenberg

Journals

Frontiers in Neuroscience

Actions

Institutions

University of California, Los Angeles

References and Citations

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Building similarity graph...

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First computational characterization of HTR5A-AS1: a schizophrenia-linked antisense RNA with synaptic functions

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study