Drug Repurposing to Treat Glioblastoma

Glioblastoma multiforme (GBM) is the most common malignant brain tumor. Surgical resection followed by radiotherapy and temozolomide (TMZ) is mostly used to treat GBM. However, this causes severe adverse effects and drug resistance. Therefore, a development of new drugs and therapeutic approaches to treat GBM is urgent. Recently, drug repurposing is considered to treat GBM effectively. Drug repurposing is to discover new indications of existing drugs on the basis of either experimental or clinical data. This strategy is cost- and time-saving to develop new drugs, and compromises a safety. Drug repurposing is actively conducted even in the treatment of GBM. Thus, this review addresses recent challenges of drug repurposing in GBM treatment and discusses future prospects.