Targeting super-enhancer-driven SKIL transcription by CDK7 inhibitor THZ1 to suppress gastric cancer progression

Key Points

• Targeting super-enhancer-driven transcription shows significant potential in influencing gastric cancer progression.
• Treatment with THZ1 led to a notable decrease in SKIL transcription levels in gastric cancer cells.
• Analysis focused on super-enhancer mechanisms within gastric cancer pathways, indicating key molecular interactions.
• This highlights a promising avenue for therapeutic development, warranting further investigation into CDK7 inhibitors.