GAT based attention-reweighted PPI networks uncover shared hub genes in Crohn’s disease and ulcerative colitis

Key Points

• Shared hub genes play a crucial role in the overlap between Crohn’s disease and ulcerative colitis.
• The analysis identified specific hub genes influencing disease progression in both conditions using a PPI network.
• Data was analyzed using attention-reweighted GAT approaches to uncover gene relationships across pathways.
• These findings indicate potential common therapeutic strategies for Crohn’s disease and ulcerative colitis.