March 3, 2026Open Access

Surgery vs. non-surgery for advanced cholangiocarcinoma post-conversion therapy with PD-1/PD-L1 inhibitors plus TKIs

Key Points

Surgical treatment significantly improves overall survival and progression-free survival in patients with advanced cholangiocarcinoma.
Patients initially classified as unresectable can achieve downstaging with PD-1/PD-L1 inhibitors and TKIs.
Assessment using a conversion surgery approach demonstrates its safety and feasibility for these patients.
Implications suggest that surgical interventions following conversion therapy may enhance patient outcomes.

Abstract

For patients with initially unresectable CCA, PD-1/PD-L1 inhibitors plus TKIs can successfully downstage the tumor. Conversion surgery is safe and feasible, and surgical treatment can improve patients' OS and PFS.

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Discussion

Authors

Zengpeng Sun

Yutao Wang

Xu Chen

Journals

Frontiers in Immunology

Actions

Institutions

Hunan Normal University

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Building similarity graph...

Analyzing shared references across papers

Surgery vs. non-surgery for advanced cholangiocarcinoma post-conversion therapy with PD-1/PD-L1 inhibitors plus TKIs

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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