Juvenile toxicity and developmental safety of Zintrodiazine, a novel antimalarial candidate, in Wistar rats

Key Points

• Zintrodiazine exhibits no adverse effects on growth or neurodevelopment in juvenile Wistar rats, supporting its safety profile.
• At clinically relevant exposures, Zintrodiazine ensures safe sexual maturation without harmful side effects.
• The findings are crucial regulatory data, enabling Zintrodiazine's progression into pediatric clinical trials.
• These results highlight the importance of developing effective antimalarial treatments for children without adverse risks.

Abstract