March 3, 2026Open Access

Oral Local Budesonide Treatment Ameliorates Immune Activation and Colonic Sensitivity in a Spontaneous Model for Disorders of Gut‐Brain Interaction

Key Points

Intestinal permeability improved significantly with budesonide treatment in the model.
Visceral hypersensitivity decreased, indicating potential for effective anti-inflammatory strategies.
Observational analysis of a spontaneous model of disorders of gut-brain interaction was conducted.
These findings highlight the importance of treating intestinal inflammation to alleviate gut-related symptoms.

Abstract

Together, these results demonstrate that a local anti-inflammatory treatment improved intestinal permeability and visceral hypersensitivity in a preclinical, spontaneous model of DGBI. Moreover, it supports a role for intestinal inflammation in the intestinal barrier defect and symptoms, further paving the way for additional evaluation of anti-inflammatory treatments, including budesonide, in DGBI.

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Authors

Alison Accarie

Pauline Huyghe

Mathieu Méleine

Journals

Neurogastroenterology & Motility

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Institutions

KU Leuven

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Oral Local Budesonide Treatment Ameliorates Immune Activation and Colonic Sensitivity in a Spontaneous Model for Disorders of Gut‐Brain Interaction

Key Points

Abstract

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Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion

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