In Vitro Analysis of TWEAK/Fn14 Axis in the Blood–Brain Barrier Models during Oxygen–Glucose Deprivation and Reoxygenation

Key Points

• In vitro analysis shows that TWEAK/Fn14 signaling is critical for maintaining blood-brain barrier integrity during episodes of oxygen-glucose deprivation and reoxygenation.
• The assessment indicates significant changes in the blood-brain barrier properties post oxygen-glucose deprivation, emphasizing the importance of this pathway in neural health.
• Observational analysis of cellular responses to TWEAK and Fn14 interactions during hypoxic conditions demonstrates potential neuroprotective strategies.
• This work highlights the necessity of further exploration of the TWEAK/Fn14 axis, as outcomes could lead to innovative treatments for neurological disorders.