FRET/SAXS integration reveals the digestion-absorption trade-off driven by dynamic self-assembly of human milk triacylglycerols

Key Points

• The integration of FRET and SAXS data shows the dynamic self-assembly of triacylglycerols significantly impacts digestion and absorption.
• Dynamic self-assembly leads to an optimal balance in nutrient absorption, which is critical for infant nutrition.
• The approach combines fluorescence resonance energy transfer (FRET) and small-angle X-ray scattering (SAXS) for comprehensive analysis of milk lipids.
• Understanding this trade-off may support improved formulations of infant nutrition products.