Short-term high-fat diet impairs anterograde and retrograde memory consolidation, but not retrieval in aged rats

Key Points

• High-fat diet specifically and significantly impairs both anterograde and retrograde memory consolidation in aged rats.
• Rats on high-fat diets exhibited measurable deficits in memory consolidation, emphasizing diet's impact on cognitive health.
• Observational study assessed memory tasks in aged rats after a short-term high-fat diet intervention.
• Findings highlight the need for dietary mindfulness in aging populations to protect cognitive functions.