Sexual Dimorphism in Clinical Manifestations of Knee Osteoarthritis

Key Points

• Distinct female-specific knee osteoarthritis manifestations include muscle degeneration and cartilage deterioration.
• Findings reveal these changes are not detectable by radiography, emphasizing the need for alternative diagnostic methods.
• Observational analysis highlights how aberrant adipogenic programming in muscle may contribute to these observed differences.
• These insights suggest further exploration into targeted treatments for knee osteoarthritis, particularly in females.

Abstract