March 3, 2026Open Access

Altered Duodenal Mucosa‐Associated Microbiota and Immune Profiles in Functional Dyspepsia: A Study of Host‐Microbiome Homeostasis

Key Points

Patients with functional dyspepsia show distinct alterations in duodenal microbiota, hinting at underlying issues.
Immune profiles in these patients differ significantly from healthy controls, highlighting a potential mechanism of disease.
Analysis suggests that host-microbiome homeostasis is disrupted in functional dyspepsia patients, affecting immune response.
This study indicates the need for further research on microbiota's role in functional dyspepsia and potential therapeutic targets.

Abstract

Our findings contribute to a growing body of evidence, indicating FD patients exhibit distinct alterations in d-MAM and immune profiles compared to controls. Furthermore, the immune-microbiome associations within control populations were absent in FD patients, suggesting a loss of host-microbiome homeostasis that may contribute to FD pathophysiology.

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Authors

Emily C. Hoedt

Grace L. Burns

Seungha Kang

Journals

Neurogastroenterology & Motility

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Institutions

The University of Queensland

University of Newcastle Australia

Princess Alexandra Hospital

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Altered Duodenal Mucosa‐Associated Microbiota and Immune Profiles in Functional Dyspepsia: A Study of Host‐Microbiome Homeostasis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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