DNA damage-driven cGAS-STING activation via a nuclear-targeted probe enables potent near-infrared theranostics in breast cancer

Key Points

• Enhanced cGAS-STING activation leads to potent theranostic effects in breast cancer.
• Using a nuclear-targeted probe, significant DNA damage effectively triggers the desired response.
• Experiments demonstrate that near-infrared light can modulate therapeutic outcomes with this approach.
• Indicates potential advancements in treatment protocols, though clinical validation in humans is needed.