March 3, 2026Open Access

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder

Key Points

Sustained antidepressant use is influenced by phenotypic factors, highlighting their significance.
The study found treatment complexity associated with specific polygenic scores (PGSs) for certain traits.
Observational analysis across different treatment groups indicates a limited correlation with sustained-use outcomes.
Identifying phenotypic associations may help inform targeted interventions for difficult-to-treat depression.

Abstract

This study found that phenotypic factors were associated with sustained antidepressant use and treatment complexity. PGSs for traits studied were associated with treatment complexity but showed little association with sustained-use 360 groups. These findings support further research to guide treatment selection and to identify patients at risk of difficult-to-treat depression, informing precision psychiatry and early intervention in MDD.

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Discussion

Authors

Alicia C. Walker

Brittany L. Mitchell

Lin Tian

Journals

JAMA Psychiatry

Actions

Institutions

University of Oxford

University of Cambridge

The University of Queensland

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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