Gestational sevoflurane exposure induces amino acid metabolic reprogramming and cognitive deficits in offspring

Key Points

• Cognitive deficits are observed in offspring exposed to sevoflurane in gestation, highlighting significant developmental impacts.
• The study identified altered amino acid metabolism as a key factor associated with cognitive deficits, signaling potential pathways involved.
• Assessment utilized a combination of behavioral tests and metabolic profiling to evaluate the effects of sevoflurane exposure on the offspring.
• Findings suggest the need for cautious use of sevoflurane during pregnancy, highlighting potential long-term consequences for children.